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PharmAccess is a group of non-profit organizations dedicated to improving access to quality healthcare in Africa. PharmAccess mobilizes public and private resources for the benefit of doctors and patients through clinical standards and quality improvements, loans for healthcare providers, health insurance, mHealth innovations and operational research.

This integrated approach is made possible by the following organizations:

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PharmAccess Foundation
AHTC, Tower 4C
Paasheuvelweg 25
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E: info@pharmaccess.org

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  • Mar 23, 2012

Second-Line Antiretroviral Treatment Successfully Resuppresses Drug-Resistant HIV-1 After First-Line Failure: Prospective Cohort in Sub-Saharan Africa

Little is known about the effect of human immunodeficiency virus type 1 (HIV-1) resistance mutations present at time of regimen switch on the response to second-line antiretroviral therapy in Africa.

In adults who switched to boosted protease inhibitor-based regimens after first-line failure, HIV-RNA and genotypic resistance testing was performed at switch and after 12 months. Factors associated with treatment failure were assessed using logistic regression. Of 243 participants, 53% were predicted to receive partially active second-line regimens due to drug resistance. The risk of treatment failure was, however, not increased in these participants. In this African cohort, boosted protease inhibitors successfully resuppressed drug-resistant HIV after first-line failure.

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Tags: Africa HIV

Suggested further reads

NCD-RisC paper on global trends in risk factors for non-communicable diseases
The Non-Communicable Disease Risk Factor Collaboration (NCD-RisC) has collected and analysed data from over 2,545 population-based studies in almost 200 countries, on major risk factors for non-communicable diseases. The Amsterdam Institute for Global Health and Development (AIGHD) and PharmAccess contributed to this research by delivering data from their impact evaluations in Nigeria and Namibia.
Dec 04, 2017 publication
The Economist publishes white paper on Global Access to Healthcare
The report, compiled with among others insights from a broad range of experts including two PharmAccess directors, examines the challenges and opportunities countries face as they attempt to improve access to high-quality healthcare.
Jun 22, 2017 publication
Report on the in-clinic research of the AIGHD within participating clinics in the Health Insurance Fund project in Nigeria from 2007 till 2011
This paper provides an updated analysis of the enrollment and health care utilization data from Hygeia
Community Health Care (HCHC).
Aug 31, 2016 publication
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